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Sports 25 , e381e391 (2015)

Their ALS progressed slower, and these patients survived much longer than an untreated group

Isakovic et al., metformin led to significant induction of caspase-dependent apoptosis in C6 rat glioma cells, associated with c-Jun N-terminal kinase (JNK) activation, mitochondrial depolarization, and oxidative stress (49)